Compendium

Publications presenting the usage of confocal endomicroscopy (CLE) during cranial procedures

2 July 2024 · 5 min read

Compiled by ZEISS Medical Technology

Summary

List of scientific publications on CLE aiding in intraoperative tissue microstructure assessment

In this compendium, ZEISS presents clinical articles on the application of CLE technology in cranial procedures with a focus on the visualization of tissue microstructure. Relevant aspects that are additionally covered include: technology aspects, workflow enhancement and economic impact. The aim is to provide further information and share knowledge.

Each publication is based on the author´s own professional opinion or on their study results. It does not necessarily reflect the opinion of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or intended purpose of our medical devices. Therefore, suitability of clinical application for each publication should be carefully assessed by the concerned physician.

Year	Titel	Link	Journal	Authors
2024 May	Intraoperative in vivo confocal endomicroscopy of the glioma margin: performance assessment of image interpretation by neurosurgeon users	Full Text	Frontiers in Oncology	Xu Y, On TJ, Abramov I, Restelli F, Belykh E, Mathis AM, Schlegel J, Hewer E, Pollo B, Maragkou T, Quint K, Porter RW, Smith KA, Preul MC
2024 Jan	Fluorescein-stained confocal laser endomicroscopy versus conventional frozen section for intraoperative histopathological assessment of intracranial tumors	Full Text	Neuro-Oncology	Wagner A, Brielmaier MC, Kampf C, Baumgart L, Aftahy AK, Meyer HS, Kehl V, Höhne J, Schebesch KM, Schmidt NO, Zoubaa S, Riemenschneider MJ, Ratliff M, Enders F, von Deimling A, Liesche-Starnecker F, Delbridge C, Schlegel J, Meyer B, Gempt J
2023 Sep	Intraoperative confocal laser endomicroscopy for interpretation of a sellar hemangioblastoma: illustrative case	Full Text	Journal of Neurosurgery	Abramov I, Furey CG, Xu Y, Eschbacher JM, Smith KA, Preul MC
2023 Aug	Intraoperative in vivo confocal laser endomicroscopy imaging at glioma margins: can we detect tumor infiltration?	Abstract	Journal of Neurosurgery	Xu Y, Mathis AM, Pollo B, Schlegel J, Maragkou T, Seidel K, Schucht P, Smith KA, Porter RW, Raabe A, Little AS, Sanai N, Agbanyim DC, Martirosyan NL, Eschbacher JM, Quint K, Preul MC, Hewer E
2022 Sep	Introduction of In Vivo Confocal Laser Endomicroscopy and Real-Time Telepathology for Remote Intraoperative Neurosurgery-Pathology Consultation	Abstract	Operative Neurosurgery	Park MT, Abramov I, Gooldy TC, Smith KA, Porter RW, Little AS, Lawton MT, Eschbacher JM, Preul MC
2022 Jun	Real-time intraoperative surgical telepathology using confocal laser endomicroscopy	Full Text	Neurosurgical Focus	Abramov I, Park MT, Gooldy TC, Xu Y, Lawton MT, Little AS, Porter RW, Smith KA, Eschbacher JM, Preul MC
2022	A new study protocol for in vivo assessment of tumor diagnosis and microscopic tumor infiltration at the resection cavity in Central Nervous System tumors by a new miniature confocal endomicroscope (CONVIVO system)	Read	Journal of Neurosurgical Sciences	Restelli F, Mazzapicchi E, Pollo B, Falco J, Bonomo G, La Corte E, Broggi M, Schiariti M, Di Meco F, Ferroli P, Tramacere I, Acerbi F
2022	Intraoperative confocal laser endomicroscopy: prospective in vivo feasibility study of a clinical-grade system for brain tumors	Read	Journal of Neurosurgery	Abramov I, Park MT, Belykh E, Dru AB, Xu Y, Gooldy TC, Scherschinski L, Farber SH, ittle AS, Porter RW, Smith KA, Lawton MT, Eschbacher JM, Preul MC
2021	Intraoperative imaging of brain tumors with fluorescein: confocal laser endomicroscopy in neurosurgery. Clinical and user experience	Read	Neurosurgical Focus FOC	Höhne J, Schebesch KM, Zoubaa S, Proescholdt M, Riemenschneider MJ, Schmidt NO
2020	Ex Vivo Fluorescein-Assisted Confocal Laser Endomicroscopy (CONVIVO^® System) in Patients With Glioblastoma: Results From a Prospective Study	Read	Frontiers in Oncology	Acerbi F, Pollo B, De Laurentis C, Restelli F, Falco J, Vetrano IG, Broggi M, Schiariti M, Tramacere I, Ferroli P, DiMeco F
2020	Confocal laser endomicroscopy assessment of pituitary tumor microstructure: A feasibility study	Read	Journal of Clinical Medicine	Belykh E, Ngo B, Farhadi DS, Zhao X, Mooney MA, White WL, Daniels JK, Little AS, Eschbacher JM, Preul MC
2020	Intraoperative Confocal Laser Endomicroscopy Ex Vivo Examination of Tissue Microstructure During Fluorescence-Guided Brain Tumor Surgery	Read	Frontiers in Oncology	Belykh E, Zhao X, Ngo B, Farhadi DS, Byvaltsev VA, Eschbacher JM, Nakaji P, Preul MC
2018	Confocal scanning microscopy provides rapid, detailed intraoperative histological assessment of brain neoplasms: Experience with 106 cases	Read	Clinical Neurology and Neurosurgery	Martirosyan NL, Georges J, Eschbacher JM, Belykh E, Carotenuto A, Spetzler RF, Nakaji P, Preul MC
2017	Confocal Laser Endomicroscopy in Neurosurgery—An Alternative to Instantaneous Sections?	Read	World Neurosurgery	Breuskin D, Szczygielski J, Urbschat S, Kim YJ, Oertel J
2016	Prospective evaluation of the utility of intraoperative confocal laser endomicroscopy in patients with brain neoplasms using fluorescein sodium: Experience with 74 cases	Read	Neurosurgical Focus	Martirosyan NL, Eschbacher JM, Yashar M, Turner JD, Belykh E, Spetzler RF, Nakaji P, Preul MC
2016	Intraoperative Probe-Based Confocal Laser Endomicroscopy in Surgery and Stereotactic Biopsy of Low-Grade and High-Grade Gliomas: A Feasibility Study in Humans	Read	Neurosurgery	Pavlov V, Meyronet D, Meyer-Bisch V, Armoiry X, Pikul B, Dumot C, Beuriat PA, Signorelli F, Guyotat J
2015	Confocal laser endomicroscopy for real-time histomorphological diagnosis: Our clinical experience with 150 brain and spinal tumor cases	Read	Neurosurgery	Charalampaki P, Javed M, Daali S, Heiroth HJ, Igressa A, Weber F
2012	In vivo intraoperative confocal microscopy for real-time histopathological imaging of brain tumors: Clinical article	Read	Journal of Neurosurgery	Eschbacher J, Martirosyan NL, Nakaji P, Sanai N, Preul MC, Smith KA, Coons SW, Spetzler RF
2011	Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas: Clinical article	Read	Journal of Neurosurgery	Sanai N, Snyder LA, Honea NJ, Coons SW, Eschbacher JM, Smith KA, Spetzler RF
2010	Confocal neurolasermicroscopy in human brain perspectives for neurosurgery on a cellular level (including additional Comments to this article)	Read	Zentralblatt fur Neurochirurgie	Schlosser HG, Suess O, Vajkoczy P, Van Landeghem FK, Zeitz M, Bojarski C

Year	Titel	Link	Journal	Authors
2021	Visualization of brain microvasculature and blood flow in vivo: Feasibility study using confocal laser endomicroscopy	Read	Microcirculation	Belykh E, Zhao X, Ngo B, Farhadi DS, Kindelin A, Ahmad S, Martirosyan NL, Lawton MT, Preul MC
2018	Diagnostic Accuracy of a Confocal Laser Endomicroscope for In Vivo Differentiation Between Normal Injured And Tumor Tissue During Fluorescein-Guided Glioma Resection: Laboratory Investigation	Read	World Neurosurgery	Belykh E, Miller EJ, Patel AA, Yazdanabadi MI, Martirosyan NL, Yağmurlu K, Bozkurt B, Byvaltsev VA, Eschbacher JM, Nakaji P, Preul MC
2013	Miniaturized handheld confocal microscopy identifies focal brain invasion in a mouse model of aggressive meningioma	Read	Brain Pathology	Peyre M, Clermont-Taranchon E, Stemmer-Rachamimov A, Kalamarides M
2012	Confocal laser endomicroscopy for diagnosis and histomorphologic imaging of brain tumors in vivo	Read	PLoS ONE	Foersch S, Heimann A, Ayyad A, Spoden GA, Florin L, Mpoukouvalas K, Kiesslich R, Kempski O, Goetz M, Charalampaki P

Year	Titel	Link	Journal	Authors
2022	Characterization of ex vivo and in vivo intraoperative neurosurgical confocal laser endomicroscopy imaging	Read	Frontiers in Oncology	Xu Y, Abramov I, Belykh E, Mignucci-Jiménez G, Park MT, Eschbacher JM, Preul MC
2021	Redosing of Fluorescein Sodium Improves Image Interpretation During Intraoperative Ex Vivo Confocal Laser Endomicroscopy of Brain Tumors	Read	Frontiers in Oncology	Abramov I, Dru AB, Belykh E, Park MT, Bardonova L, Preul MC
2021	High-Dose Fluorescein Reveals Unusual Confocal Endomicroscope Imaging of Low-Grade Glioma	Read	Frontiers in Neurology	Belykh E, Onaka NR, Zhao X, Abramov I, Eschbacher JM, Nakaji P, Preul MC
2021	Fluorescence-Guided Surgery: A Review on Timing and Use in Brain Tumor Surgery	Read	Frontiers in Neurology	Schupper AJ, Rao M, Mohammadi N, Baron R, Lee JY, Acerbi F, Hadjipanayis CG
2020	Blood-Brain Barrier, Blood-Brain Tumor Barrier, and Fluorescence-Guided Neurosurgical Oncology: Delivering Optical Labels to Brain Tumors	Read	Frontiers in Oncology	Belykh E, Shaffer KV, Lin C, Byvaltsev VA, Preul MC, Chen L
2019	Progress in Confocal Laser Endomicroscopy for Neurosurgery and Technical Nuances for Brain Tumor Imaging With Fluorescein	Read	Frontiers in Oncology	Belykh E, Miller EJ, Carotenuto A, Patel AA, Cavallo C, Martirosyan NL, Healey DR, Byvaltsev VA, Scheck AC, Lawton MT, Eschbacher JM, Nakaji P, Preul MC
2018	Dual-labeling with 5-aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: Technical note	Read	Journal of Neurosurgery	Molina ES, Wölfer J, Ewelt C, Ehrhardt A, Brokinkel B, Stummer W
2018	Probe-based three-dimensional confocal laser endomicroscopy of brain tumors: Technical note	Read	Cancer Management and Research	Belykh E, Patel AA, Miller EJ, Bozkurt B, Yağmurlu K, Woolf EC, Scheck AC, Eschbacher JM, Nakaji P, Preul MC

Year	Titel	Link	Journal	Authors
2022 Oct	Confocal laser imaging in neurosurgery: A comprehensive review of sodium fluorescein-based CONVIVO preclinical and clinical applications	Full Text	Frontiers in Oncology	Restelli F, Mathis AM, Höhne J, Mazzapicchi E, Acerbi F, Pollo B, Quint K
2021	Confocal laser microscopy in neurosurgery: State of the art of actual clinical applications	Read	Journal of Clinical Medicine	Restelli F, Pollo B, Vetrano IG, Cabras S, Broggi M, Schiariti M, Falco J, de Laurentis C, Raccuia G, Ferroli P, Acerbi F
2018	Utilization of intraoperative confocal laser endomicroscopy in brain tumor surgery	Read	Journal of Neurosurgical Sciences	Belykh E, Cavallo C, Gandhi S, Zhao X, Veljanoski D, Yazdanabadi MI, Martirosyan NL, Byvaltsev VA, Eschbacher J, Preul MC, Nakaji P

Year	Titel	Link	Journal	Authors
2022 Nov	Intraoperative confocal laser endomicroscopy for brain tumors - potential and challenges from a neuropathological perspective	Full Text	Free Neuropathology	Maragkou T, Quint K, Pollo B, Hewer E
2022	Real-time intraoperative surgical telepathology using confocal laser endomicroscopy	Read	Journal of Neurosurgery	Abramov I, Park MT, Gooldy TC, Xu Y, Lawton MT, Little AS, Porter RW, Smith KA, Eschbacher JM, Preul MC
2021	Socio-organizational impact of confocal laser endomicroscopy in neurosurgery and neuropathology: Results from a process analysis and expert survey	Read	Diagnostics	Fotteler ML, Liesche-Starnecker F, Brielmaier MC, Schobel J, Gempt J, Schlegel J, Swoboda W
2000	Accuracy, Utility, and Cost of Frozen Section Margins in Head and Neck Cancer Surgery	Read	The Laryngoscope	Dinardo LJ, Lin J, Karageorge LS, Powers CN
2019	In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice	Read	Archives of pathology & laboratory medicine	Wells WA, Thrall M, Sorokina A, Fine J, Krishnamurthy S, Haroon A, Rao B, Shevchuk MM, Wolfsen HC, Tearney GJ, Hariri LP
2019	Clinical Benefits of Combining Different Visualization Modalities in Neurosurgery	Read	Frontiers in Surgery	Schebesch KM, Rosengarth K, Brawanski A, Proescholdt M, Wendl C, Höhne J, Ott C, Lamecker H, Doenitz C
2019	In vivo and ex vivo microscopy: A business plan to justify the introduction of similar emerging technologies into pathology practice	Read	Archives of Pathology and Laboratory Medicine	Wells WA, Harhen MT, Thrall MJ, Shevchuk MM, Tearney GJ, Hariri LP
2019	Toward Quantitative Neurosurgical Guidance With High-Resolution Microscopy of 5-Aminolevulinic Acid-Induced Protoporphyrin IX	Read	Frontiers in Oncology	Wei L, Fujita Y, Sanai N, Liu JT

Year	Titel	Link	Journal	Authors
2021	Fluorescein-Guided Panendoscopy for Head and Neck Cancer Using Handheld Probe-Based Confocal Laser Endomicroscopy: A Pilot Study	Read	Frontiers in Oncology	Dittberner A, Ziadat R, Hoffmann F, Pertzborn D, Gassler N, Guntinas-Lichius O
2021	Confocal laser endomicroscopy of head and neck squamous cell carcinoma: a systematic review	Read	Laryngo- Rhino- Otologie	Sievert M, Auberville M, Oetter N, Stelzle F, Maier A, Mantsopoulos K, Iro H, Goncalves M
2021	Intraoperative free margins assessment of oropharyngeal squamous cell carcinoma with confocal laser endomicroscopy: a pilot study	Read	European Archives of Oto-Rhino-Laryngology	Sievert M, Stelzle F, Aubreville M, Mueller SK, Eckstein M, Oetter N,Maier A, Mantsopoulos K, Iro H, Goncalves M
2019	Probe-based confocal laser endomicroscopy for diagnosis of nasopharyngeal carcinoma in vivo	Read	The Laryngoscope	Wu L, Yu H, Zhou R, Luo J, Zhao J, Li Y, Wang K, Wang Y, Li H
2019	Probe-based confocal laser endomicroscopy in detecting malignant lesions of vocal folds	Read	Acta Otorhinolaryngologica Italica	Goncalves M, Aubreville M, Mueller SK, Sievert M, Maier A, Iro H, Bohr C
2017	Value of confocal laser endomicroscopy in the diagnosis of vocal cord lesions	Read	European review for medical and pharmacological sciences	Goncalves M, Iro H, Dittberner A, Agaimy A, Bohr C
2016	Evaluation of confocal laser endomicroscopy as an aid to differentiate primary flat lesions of the larynx: A prospective clinical study	Read	Head & Neck	Volgger V, Girschick S, Ihrler S, Englhard AS, Stepp H, Betz CS
2016	Noninvasive histological imaging of head and neck squamous cell carcinomas using confocal laser endomicroscopy	Read	European Archives of Oto-Rhino-Laryngology	Linxweiler M, Kadah BA, Bozzato A, Bozzato V, Hasenfus A, Kim YJ, Wagner M,Igressa A, Schick B, Charalampaki P
2012	Systematic intraoperative application of confocal endomicroscopy for early detection and resection of squamous cell carcinoma of the head and neck: A preliminary report	Read	Archives of Otolaryngology - Head and Neck Surgery	Pogorzelski B, Hanenkamp U, Goetz M, Kiesslich R, Gosepath J

Year	Titel	Link	Journal	Authors
2015	Confocal laser endomicroscopy in breast surgery: A pilot study	Read	BMC Cancer	De Palma GD, Esposito D, Luglio G, Limite G, Accurso A, Sollazzo V, Maione F, Cassese G, Siciliano S, Gennarelli N, Ilardi G, Paternoster M, Giglio MC, Forestieri P
2015	Imaging breast cancer morphology using probe-based confocal laser endomicroscopy: towards a real-time intraoperative imaging tool for cavity scanning	Read	Breast Cancer Research and Treatment	Chang TP, Leff DR, Shousha S, Hadjiminas DJ, Ramakrishnan R, Hughes MR, Yang GZ, Darzi A
2014	Fluorescence confocal microscopy for pathologists	Read	Modern Pathology	Ragazzi M, Piana S, Longo C, Castagnetti F, Foroni M, Ferrari G, Gardini G, Pellacani G

Year	Titel	Link	Journal	Authors
2021	Deep Neural Network for Differentiation of Brain Tumor Tissue Displayed by Confocal Laser Endomicroscopy	Read	Frontiers in Oncology	Ziebart A, Stadniczuk D, Roos V, Ratliff M, von Deimling A, Hänggi D, Enders F
2018	Context aware decision support in neurosurgical oncology based on an efficient classification of endomicroscopic data	Read	International Journal of Computer Assisted Radiology and Surgery	Li Y, Charalampaki P, Liu Y, Yang GZ, Giannarou S
2018	Convolutional neural networks: Ensemble modeling, fine-tuning and unsupervised semantic localization for neurosurgical CLE images	Read	Journal of Visual Communication and Image Representation	Izadyyazdanabadi M, Belykh E, Mooney M, Martirosyan N, Eschbacher J, Nakaji P, Preul MC, Yang Y
2018	Weakly-supervised learning-based feature localization for confocal laser endomicroscopy glioma images	Read	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)	Izadyyazdanabadi M, Belykh E, Cavallo C, Zhao X, Gandhi S, Moreira LB, Eschbacher J, Nakaji P, Preul MC, Yang Y
2018	Prospects for theranostics in neurosurgical imaging: Empowering confocal laser endomicroscopy diagnostics via deep learning	Read	Frontiers in Oncology	Izadyyazdanabadi M, Belykh E, Mooney MA, Eschbacher JM, Nakaji P, Yang Y, Preul MC
2016	Automatic Tissue Differentiation Based on Confocal Endomicroscopic Images for Intraoperative Guidance in Neurosurgery	Read	BioMed Research International	Kamen A, Sun S, Wan S, Kluckner S, Chen T, Gigler AM, Simon E, Fleischer M, Javed M, Daali S, Igressa A, Charalampaki P

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Publications presenting the usage of confocal endomicroscopy (CLE) during cranial procedures

List of scientific publications on CLE aiding in intraoperative tissue microstructure assessment

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