INTRAGO-I: Estudio de dosis escalonadas de radioterapia intraoperatoria (RIO) en glioblastoma multiforme (GBM)
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La lectura de este breve resumen no sustituye la lectura del estudio original, sino que solo aporta información sintetizada y que no necesariamente refleja la opinión de los organismos notificados ni de las autoridades reguladoras, como DQS o la FDA.
Breve resumen del estudio de dosis escalonadas INTRAGO-I creado por el Dr. Frank A. Giordano en nombre de ZEISS, marzo de 2019.
Título original:
INTRAGO: radioterapia intraoperatoria en glioblastoma multiforme: estudio de aumento de dosis de fase I/II
Autores:
Frank A. Giordano, Stefanie Brehmer, Yasser Abo-Madyan, Grit Welzel, Elena Sperk, Anke Keller,
Frank Schneider, Sven Clausen, Carsten Herskind, Peter Schmiedek y Frederik Wenz
Fuente:
Giordano, F. A., Brehmer, S., Abo-Madyan, Y., Welzel, G., Sperk, E., Keller, A., … Wenz, F. (2014).
INTRAGO: intraoperative radiotherapy in glioblastoma multiforme – a Phase I/II dose escalation study.
BMC Cancer, 14(1), 992.
- El glioblastoma multiforme (GBM) es el principal tumor cerebral primario maligno en adultos. Prácticamente todos los casos de GBM presentan recurrencia, el riesgo más elevado aparece en el lecho tumoral.
- Siguiendo el protocolo de tratamiento estándar para GBM primario, el tiempo de supervivencia libre de progresión tiene una media de 7 meses, con una supervivencia global típica de unos 15 meses.
- INTRAGO es el primer estudio de dosis escalonadas en fase I/II para GBM recientemente diagnosticados que investiga la adición de terapia de radiación intraoperatoria (RIO) al tratamiento estándar de radioquimioterapia para GBM recientemente diagnosticados usando el dispositivo INTRABEAM® de Carl Zeiss Meditec AG.
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