![製薬・バイオファーマ – 科学の探求から疾患の予防・治療・回復まで 製薬・バイオファーマ – 科学の探求から疾患の予防・治療・回復まで]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-pharma-solutions.jpg/_jcr_content/renditions/original.image_file.100.56.file/zeiss-pharma-solutions.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-pharma-solutions.jpg/_jcr_content/renditions/original.image_file.360.203.file/zeiss-pharma-solutions.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-pharma-solutions.jpg/_jcr_content/renditions/original.image_file.768.432.file/zeiss-pharma-solutions.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-pharma-solutions.jpg/_jcr_content/renditions/original.image_file.1024.576.file/zeiss-pharma-solutions.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-pharma-solutions.jpg/_jcr_content/renditions/original.image_file.1280.720.file/zeiss-pharma-solutions.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-pharma-solutions.jpg/_jcr_content/renditions/original.image_file.1440.810.file/zeiss-pharma-solutions.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-pharma-solutions.jpg/_jcr_content/renditions/original./zeiss-pharma-solutions.jpg"})
製薬・バイオファーマ 科学の探求から疾患の予防・治療・回復まで
![ニューロスフェア。試料ご提供:H. Braun, LSM Bioanalytik GmbH, Magdeburg, Germany ニューロスフェア。試料ご提供:H. Braun, LSM Bioanalytik GmbH, Magdeburg, Germany]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.100.56.8,0,1918,1076.file/early-basic-research.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.360.203.8,0,1918,1076.file/early-basic-research.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.768.432.8,0,1918,1076.file/early-basic-research.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.1024.576.8,0,1918,1076.file/early-basic-research.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.1280.720.8,0,1918,1076.file/early-basic-research.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.1440.810.8,0,1918,1076.file/early-basic-research.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.1910.1074.8,0,1918,1076.file/early-basic-research.jpg"})
ニューロスフェア。試料ご提供:H. Braun, LSM Bioanalytik GmbH, Magdeburg, Germany
初期の基礎研究
創薬のターゲット候補を決定する前に、疾患の発症機序を詳しく理解することが重要です。この初期の基礎研究によって、新たな超大型医薬品開発の戦略を立てるのに必要な知識とフレームワークが得られます。ZEISSは、細胞生物学者、癌研究者、神経科学者などのライフサイエンス研究者向けの、最先端のイメージングシステムとAI画像解析の強力なポートフォリオをご用意しています。
![創薬 創薬]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-discovery-celldiscoverer.jpg/_jcr_content/renditions/original.image_file.100.56.file/drug-discovery-celldiscoverer.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-discovery-celldiscoverer.jpg/_jcr_content/renditions/original.image_file.360.203.file/drug-discovery-celldiscoverer.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-discovery-celldiscoverer.jpg/_jcr_content/renditions/original.image_file.768.432.file/drug-discovery-celldiscoverer.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-discovery-celldiscoverer.jpg/_jcr_content/renditions/original.image_file.1024.576.file/drug-discovery-celldiscoverer.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-discovery-celldiscoverer.jpg/_jcr_content/renditions/original.image_file.1280.720.file/drug-discovery-celldiscoverer.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-discovery-celldiscoverer.jpg/_jcr_content/renditions/original.image_file.1440.810.file/drug-discovery-celldiscoverer.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-discovery-celldiscoverer.jpg/_jcr_content/renditions/original./drug-discovery-celldiscoverer.jpg"})
創薬
創薬は基礎研究と本格的な医薬品開発をつなぐステージであり、開発プログラムの戦略に関する重要な決定を下すことが求められます。ターゲット分子の選択からリード化合物の同定のフェノタイプスクリーニングまで、R&Dに必要な時間と資源を効率化するには、堅実な戦略を練る必要があります。
![医薬品開発 医薬品開発]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-life-science-portfolio.jpg/_jcr_content/renditions/original.image_file.100.56.8,0,1918,1076.file/zeiss-life-science-portfolio.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-life-science-portfolio.jpg/_jcr_content/renditions/original.image_file.360.203.8,0,1918,1076.file/zeiss-life-science-portfolio.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-life-science-portfolio.jpg/_jcr_content/renditions/original.image_file.768.432.8,0,1918,1076.file/zeiss-life-science-portfolio.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-life-science-portfolio.jpg/_jcr_content/renditions/original.image_file.1024.576.8,0,1918,1076.file/zeiss-life-science-portfolio.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-life-science-portfolio.jpg/_jcr_content/renditions/original.image_file.1280.720.8,0,1918,1076.file/zeiss-life-science-portfolio.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-life-science-portfolio.jpg/_jcr_content/renditions/original.image_file.1440.810.8,0,1918,1076.file/zeiss-life-science-portfolio.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-life-science-portfolio.jpg/_jcr_content/renditions/original.image_file.1910.1074.8,0,1918,1076.file/zeiss-life-science-portfolio.jpg"})
医薬品開発
少数精鋭のリード化合物を体系的に最適化して臨床試験に向けて開発するには、慎重な選択プロセスが求められます。リード化合物の作用機序や薬理学的・毒物学的特性を十分に理解し、ヒトに対する初めての研究で使われる、安全で有効な用法・用量を決定するためのデータベースを構築することが特に重要です。また、疾患に特化し、個人に合わせた医薬品の開発が進められています。
![製薬と品質管理 製薬と品質管理]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-manufacturing.jpg/_jcr_content/renditions/original.image_file.100.56.8,0,1918,1076.file/drug-manufacturing.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-manufacturing.jpg/_jcr_content/renditions/original.image_file.360.203.8,0,1918,1076.file/drug-manufacturing.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-manufacturing.jpg/_jcr_content/renditions/original.image_file.768.432.8,0,1918,1076.file/drug-manufacturing.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-manufacturing.jpg/_jcr_content/renditions/original.image_file.1024.576.8,0,1918,1076.file/drug-manufacturing.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-manufacturing.jpg/_jcr_content/renditions/original.image_file.1280.720.8,0,1918,1076.file/drug-manufacturing.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-manufacturing.jpg/_jcr_content/renditions/original.image_file.1440.810.8,0,1918,1076.file/drug-manufacturing.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-manufacturing.jpg/_jcr_content/renditions/original.image_file.1910.1074.8,0,1918,1076.file/drug-manufacturing.jpg"})
製薬と品質管理
臨床試験でも、規制当局(FDA、EMA、NMPAなど)による新薬販売承認後でも、医薬品には最高水準の品質が求められます。製造管理および品質管理に関する基準(GMP)への準拠は、不純物などの医薬品の欠陥を体系的に防ぐために重要です。製造過程の問題を完全に回避することは難しいものの、メーカーが製造承認を維持し医薬品を販売するには、問題を迅速に発見、ドキュメンテーション、解決することが求められます。