Gaining molecular insights with ZEISS Dynamics Profiler

20 June 2023

Jena, Germany | 20 June 2023 | ZEISS Research Microscopy Solutions

ZEISS Dynamics Profiler is adding a new functionality to ZEISS laser scanning microscopes (LSM) with Airyscan. It provides users with easy access to the molecular concentration and dynamics of fluorescently labelled molecules in living samples. Scientists can now explore their most delicate samples with little time needed and at low light intensity as well as boost data collection to enhance their research.

ZEISS
Flow measurement with ZEISS Dynamics Profiler: To determine the flow direction and speed within a liquid, 27 detector element pairs are cross-correlated along three different axes of the ZEISS Airyscan detector.

ZEISS
Flow measurement with ZEISS Dynamics Profiler: To determine the flow direction and speed within a liquid, 27 detector element pairs are cross-correlated along three different axes of the ZEISS Airyscan detector.
ZEISS
Asymmetric diffusion measurement with ZEISS Dynamics Profiler: Polar heatmaps visualize the diffusion behavior of molecules within a measurement spot.

ZEISS
Asymmetric diffusion measurement with ZEISS Dynamics Profiler: Polar heatmaps visualize the diffusion behavior of molecules within a measurement spot.

Seamless integration with live imaging experiments

Fluorescence Correlation Spectroscopy (FCS) is an established method for investigating molecular characteristics. However, it requires low concentrations of fluorescent label – which hinders its use in most live imaging experiments. ZEISS Dynamics Profiler is the first tool with an intuitive and easy-to-use interface to provide effortless access to this data during confocal live imaging experiments.

New spatial cross-correlation analyses

The area detector allows a variety of spatial cross-correlation analyses by using combinations of the 32 single Airyscan detector elements. Besides conventional FCS measurements of molecular concentration and mobility, it also enables the study of the asymmetric diffusion behavior of cellular condensates, for example, as well as the measurement of speed and direction of molecules moving in a bloodstream or in microfluidic systems, such as organs-on-a-chip. Scientists can develop a more in-depth profile of underlying molecular dynamics in their experiments – from cell cultures to organoids to whole organisms.

ZEISS Dynamics Profiler product page

Press Contact Vybhav Sinha ZEISS Research Microscopy Solutions

About ZEISS

ZEISS is an internationally leading technology enterprise operating in the fields of optics and optoelectronics. In the previous fiscal year, the ZEISS Group generated annual revenue totaling 8.8 billion euros in its four segments Semiconductor Manufacturing Technology, Industrial Quality & Research, Medical Technology and Consumer Markets (status: 30 September 2022).

For its customers, ZEISS develops, produces and distributes highly innovative solutions for industrial metrology and quality assurance, microscopy solutions for the life sciences and materials research, and medical technology solutions for diagnostics and treatment in ophthalmology and microsurgery. The name ZEISS is also synonymous with the world's leading lithography optics, which are used by the chip industry to manufacture semiconductor components. There is global demand for trendsetting ZEISS brand products such as eyeglass lenses, camera lenses and binoculars.

With a portfolio aligned with future growth areas like digitalization, healthcare and Smart Production and a strong brand, ZEISS is shaping the future of technology and constantly advancing the world of optics and related fields with its solutions. The company's significant, sustainable investments in research and development lay the foundation for the success and continued expansion of ZEISS' technology and market leadership. ZEISS invests 13 percent of its revenue in research and development – this high level of expenditure has a long tradition at ZEISS and is also an investment in the future.

With over 40,000 employees, ZEISS is active globally in almost 50 countries with around 30 production sites, 60 sales and service companies and 27 research and development facilities (status: 31 March 2023). Founded in 1846 in Jena, the company is headquartered in Oberkochen, Germany. The Carl Zeiss Foundation, one of the largest foundations in Germany committed to the promotion of science, is the sole owner of the holding company, Carl Zeiss AG.

Further information at www.zeiss.com

ZEISS Research Microscopy Solutions

ZEISS Research Microscopy Solutions is the leading provider of light, electron, X-ray microscope systems, correlative microscopy and software solutions leveraging AI technologies. The portfolio comprises of products and services for life sciences, materials and industrial research, as well as education and clinical routine applications. The unit is headquartered in Jena. Additional production and development sites are located in Germany, UK, USA and China. ZEISS Research Microscopy Solutions is part of the Industrial Quality & Research segment.

Further information at www.zeiss.com/microscopy

Press photos

ZEISS Dynamics Profiler

Flow measurement with ZEISS Dynamics Profiler: To determine the flow direction and speed within a liquid, 27 detector element pairs are cross-correlated along three different axes of the ZEISS Airyscan detector.

File size: 483 KB

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ZEISS Dynamics Profiler

Asymmetric diffusion measurement with ZEISS Dynamics Profiler: Polar heatmaps visualize the diffusion behavior of molecules within a measurement spot.

File size: 504 KB

Download