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Novel Approaches to Measure Receptor-Mediated Endocytosis of Herceptin

In this case study, we sought to develop a proof-of-concept assay that could quantify Herceptin plasma-membrane binding, internalization, and trafficking to late endosomes.

3D Multiplexing Spatial Omics Workflows in Neuroscience

This case study provides a blueprint for the analysis of 3D spatial omics multiplexing datasets from a CODEX multiplex antibody panel imaged with a custom set-up using the Akoya Phenocycler and ZEISS LSM 980 confocal microscope to explore the expression of an extensive list of pre-synaptic markers in the mouse brain.

Novel Approaches to Measure Receptor-Mediated Endocytosis of Herceptin

In this case study, we sought to develop a proof-of-concept assay that could quantify Herceptin plasma-membrane binding, internalization, and trafficking to late endosomes.

Neuron Tracing

In this series "From Image to Results", explore various case studies explaining how to reach results from your demanding samples and acquired images in an efficient way. For each case study, we highlight different samples, imaging systems, and research questions. In this case study, we trace neurons.

Brain Tumor Microenvironment Spatial Biology with High-Throughput Hyperplexed Imaging

A new hyper-multiplex workflow using ZEISS Axioscan enables high-throughput Imaging of fragile tissues with 40-50 markers over large regions and high magnifications.

7 Color Multiplex Immunofluorescence Protocol for Spatial Biology with a Digital Slide Scanner

New protocol for efficient generation of seven-color, whole slide imaging with ZEISS Axioscan.

Vesicle Trafficking

In this series "From Image to Results", explore various case studies explaining how to reach results from your demanding samples and acquired images in an efficient way. For each case study, we highlight different samples, imaging systems, and research questions.

From Image to Results | Organoid Analysis

In this episode, we showcase a simple imaging experiment performed on intestinal organoids treated with and without a Wnt-inhibiting drug, with the experimental goal to study the role of Wnt signaling in organoid formation.

High Content Imaging for Genotoxicity

Key learnings from this episode explores: how to perform the general analysis with one drug and how to automate imaging and analysis procedures, to the point that the whole process can be scaled easily to perform high-content screening (HCS) or be adapted to other complex experimental settings.

High Content Analysis for Genotoxicity

See the workflow of designing an analysis pipeline using ZEISS arivis Pro and the integrated Cellpose operator to analyze 2D images from well plates for assessing the genotoxic effects of drug treatments on renal carcinoma cells.

High Content siRNA Analysis for Experimental Cytoskeleton Regulation

In this Video we review the advanced image analysis workflow applied to obtain correlative information for cytoskeleton regulation in an experimental setting.

Analyzing Influenza A Virus Entry Through Lattice Light Sheet Microscopy

A research group led by Prof. Allen Liu at the University of Michigan, USA, used ZEISS Lattice Lightsheet 7 to study cellular entry mechanisms of this virus. They focused on the membrane-bending protein epsin. Their findings support the hypothesis that epsin plays a biomechanical role in IAV entry.

Brain Tumor Microenvironment Spatial Biology with High-Throughput Hyperplexed Imaging

Dr. Spencer S. Watson, a Research Fellow in Professor Joyce’s lab, published an article investigating how the brain tumor microenvironment responds to radiotherapy, not just in terms of changes in different cell populations, but also regarding how the cells spatially organize themselves. In order to do this, the team worked to create a new multiplex workflow, called Hyperplexed Immunofluorescence Imaging (HIFI), to study the spatial biology of tumors before and after treatment.

High Content Analysis for Genotoxicity

See the workflow of designing an analysis pipeline using ZEISS arivis Pro and the integrated Cellpose operator to analyze 2D images from well plates for assessing the genotoxic effects of drug treatments on renal carcinoma cells.

Brain Tumor Microenvironment Spatial Biology with High-Throughput Hyperplexed Imaging

A newhyper-multiplex workflow using ZEISS Axioscan rnables high-throughput imaging of fragile tissues with 40-50 markers over large regions and high magnifications

AI in Microscopy: Deep Learning for Image Analysis

Key insights on advanced AI microscopy techniques including, conventional Machine Learning (ML) vs. Deep Learning for image segmentation, and Semantic vs. Instance Segmentation.

Image Analysis Made Easy with ZEISS arivis

Discover how AI-powered tools in ZEISS arivis simplify microscopy image analysis. Handle large multidimensional datasets with ease. Fill out the form to download life sciences case studies.

AI-Driven Image Analysis for Organoid Research and Analysis

Our innovative algorithms support your organoid research. From visualization to automated analysis and subcellular segmentation, we’ve got you covered. AI models help take your organoid analysis to new levels.

Taking Cell Phenotype Analysis to New Levels of Detail and Automation

Advanced image analysis examples from cancer research and cell biology

High Content Analysis For Biotech and Pharma

Our HCA solutions are designed to provide you with the tools and capabilities you need to drive groundbreaking discoveries, accelerate drug development, and unlock new frontiers in scientific exploration.

ZEISS Microscopy Image Analysis Software Solutions

Accelerate your time to results, incorporate AI, and tackle new challenges with the ZEISS arivis portfolio. Our tools are designed to support your journey regardless of what instrumentation you use.

Liver Microtissue Histopathology in Drug Development Enhanced by AI Image Analysis

Imagine that a promising new drug for chronic pain is stopped during clinical trials. Not because it is ineffective, but because it unexpectedly causes liver damage....

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