New Dimensions in Neuroscience

• Light-sheet Microscopy: Particularly useful for imaging large tissue sections like whole rodent brains, enabling experiments like long-range circuit tracing and holistic immediate early gene detection following behavior.
• Confocal Microscopy: Ideal for imaging brain slices and obtaining high-resolution images of cellular structures. Add on airyscan for near super resolution to visualize in detail dendritic spines, perineuronal nets, and glial morphology.
  Structured-illumination Microscopy: Enhances resolution beyond the diffraction limit, making it ideal for gentle imaging of fine neural structures such as synapses, dendritic spines, and protein aggregates in brain tissue with exceptional clarity.
• Electron Microscopy: Provides ultra-high resolution for detailed visualization of brain structures like synaptic vesicles and mitochondrial folds.
• Automated Imaging: Streamlines the acquisition of large datasets for high-throughput neuroscience studies, enabling applications like whole-brain mapping and multiwell plate screening of neural cultures.

These systems come together to form a versatile portfolio, empowering you to investigate the brain in whatever way your research demands—whether it's fast imaging, gentle techniques, large-area mapping, or super-resolution detail.

ZEISS microscopy solutions empower neuroscience research by offering:

• High Resolution: Our systems combine advanced optics, imaging technologies and deconvolution options that deliver exceptional detail, enabling precise visualization of structures and processes in the brain and peripheral nervous system.
• Live Imaging: Many ZEISS systems are optimized for live-cell imaging, allowing researchers to capture dynamic neural processes in real time, from protein fluidics to synaptic activity and neuronal signaling.
• Multimodal Imaging: Seamless integration of imaging modalities including widefield, confocal, and electron microscopy provides a comprehensive view the same neural sample at multiple scales.
• Advanced Image Analysis: ZEISS software solutions leverage AI and machine learning to simplify complex analyses, enabling automated segmentation, cell tracking, and quantitative measurements to extract meaningful insights from your data.
  
  

Together, these solutions enable you to unlock new insights and push the boundaries of neuroscience research.

Yes, ZEISS provides various case studies,application notes, and educational resources that highlight how our microscopy systems are advancing neuroscience research. Here are a few examples:

• Imaging Synaptic Structures: Confocal microscopy enables detailed studies of synaptic connections and plasticity, revealing the intricate mechanisms of neuronal communication.
• Neurodegenerative Disease Research: Slide-scanning microscopes automate the imaging of large brain section datasets, facilitating the identification of plaques and linking pathology to phenotypic changes in diseases like Alzheimer's.
• Brain Mapping: Advanced light-sheet microscopy allows for whole cleared brain imaging, paired with atlas registration to pinpoint immediate early gene activity and neural responses following behavioral events.

These are just a few examples—explore our website to discover more case studies, application notes, and resources tailored to your neuroscience research needs.