
Advancing Tau-opathy Research in PSP through High-Throughput and Predictive Analytics Dr. Rose B. Creed
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Click here to watch the webinar recording
Advancing Tau-opathy Research in PSP through High-Throughput and Predictive Analytics
Presentation by Dr. Rose B. Creed, Univresity of California, San Francisco
Educational resources
Explore our online resources designed to help you recreate the workflows demonstrated.
These include protocols and instructional videos on:
- Selecting antibodies and immunohistochemistry techniques for identifying tau plaques in the brain
- Step-by-step instructions for using the Axioscan 7 to image hundreds of brain section
- Leveraging arivis Pro to automatically detect tau plaques within neuronal nuclei and cell types
- Registering brain sections to the Allen Brain Atlas to assess plaque load by region
- Running secondary analysis pipelines to predict animal’s gait patterns based on regional plaque load
- Harnessing the power of complex datasets and streamlining neuroscience research through collabroative, cloud-based imaging analysis
Towards a mechanistic understanding of how Tau pathology contributes to dysfunction in progressive supranuclear palsy

Rose B. Creed is a postdoctoral fellow at the University of California, San Francisco, in the laboratory of Alexandra Nelson, M.D., Ph.D. There, she takes a systems neuroscience approach to examine how impairments in the basal ganglia circuit underlie different types of movement disorders. Rose obtained her Bachelor of Science degree in Biology at Stetson university in 2014 and received her Ph.D. from the University of Alabama at Birmingham (UAB) in summer 2020. While at UAB she worked in the labs of Drs. Matthew Goldberg and Lori McMahon, investigating how loss of function of the mitochondrial targeted kinase PINK1 impacts the striatal circuit and its implication for Parkinson’s disease.

Phil Dong earned his PhD in neuroscience from Mount Sinai School of Medicine, where he focused on calcium imaging data analysis and open-source software development. His expertise spans a wide range of data science techniques applied to systems neuroscience, including electrophysiology, imaging data analysis, behavior segmentation, data mining, visualization, statistical modeling, and artificial neural networks. In addition to his role as a Data Scientist at MetaCell, Phil is also a postdoctoral researcher, where he is working on the development of next-generation miniature microscopes for calcium imaging in behaving animals.

Natasha Mayorga is a BrAInsight Intern at ZEISS Microscopy, where she focuses on developing AI-driven workflows for neuroscience microscopy analysis. She works with cross-functional teams to create reproducible image analysis solutions and enhance user experiences with ZEISS arivis software. Natasha is a rising senior at the FAU Harriet L. Wilkes Honors College, majoring in biochemistry and data analytics. Previously, she researched drug-seeking behavior and memory associations at the Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology. Recently, she has incorporated computational techniques into her neuroscience work to bring an interdisciplinary approach to her research.

Jason Fung is a Software Applications Scientist based at the ZEISS Microscopy Customer Center in the Bay Area. With a Master's in Biomedical Engineering from the University of British Columbia and a background in applied physics and mathematics, Jason has experience coding and building deep learning based analysis tools to handle a multitude of datasets ranging from materials science applications in the clean energy space to analyzing multi-photon images for developmental neuroscience research. As a Software Applications Scientist with a unique blend of experience working on different imaging datasets, Jason provides tailored and innovative image analysis solutions using arivis to help customers answer their most pressing research questions.

Dr. Stephen Larson, co-founder and CEO of MetaCell, is an expert on the intersection between computer technology and biological systems, and is interested in how computer systems can help us understand fundamental principles of life. Dr. Larson also serves as the Executive Director for the OpenWorm Foundation. He served as the Chief Information Officer of One Mind for Research, a non-profit dedicated to eradicating brain disease by transforming the healthcare research system through public-private partnerships. He has worked as a professional software engineer for a major New York City investment bank, co-developed a patent, presented at more than two dozen forums, published in academic journals such as Frontiers in Neuroscience and Nature, and has had his work featured in the New York Times, The Atlantic, Wired, and MSNBC.com. His diverse educational background includes a Bachelor of Science and Master of Engineering from MIT in Computer Science as well as a PhD in Neuroscience from the University of California, San Diego.

Mary Phillips, PhD, is a Business Development Manager at ZEISS Microscopy, where she focuses on building strong partnerships within the academic neuroscience community and developing innovative workflows to enable advanced experiments and analysis. Mary earned her PhD in Neuroscience from the University of Alabama at Birmingham and completed her postdoctoral training in Dr. Ryohei Yasuda's laboratory at the Max Planck Florida Institute for Neuroscience. Her research explored the neural circuits underlying social cognition and memory, and she developed an imaging technique capable of distinguishing 10 neuronal subtypes within miniscope calcium recordings. Now, Mary applies her expertise to help drive scientific discovery by bridging cutting-edge imaging technologies with the evolving needs of neuroscientists.
ZEISS & MetaCell Custom Solutions
Building on this foundation, MetaCell employed machine learning techniques to analyze the correlation between Tau pathology and gait impairments in the hTau.P301S mouse model. Their analysis applied predictive models, such as Lasso regression, to identify key brain regions where Tau pathology was most strongly associated with motor deficits. This approach pinpointed 3-4 critical regions for each gait disorder subtype.
Together, ZEISS and MetaCell deliver cutting-edge analysis solutions that empower researchers to uncover new insights into disease pathology.

Check out our previous breakthrough!
Last time on BrAInsight Breakthroughs, we partnered with Dr. Mehwish Anwer from the University of British Columbia to investigate traumatic brain injury by using whole, cleared brain imaging and 3D atlas registration