![药物发现——识别能够对抗疾病的靶点和先导化合物分子 药物发现——识别能够对抗疾病的靶点和先导化合物分子]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-discovery-solutions.jpg/_jcr_content/renditions/original.image_file.100.56.file/drug-discovery-solutions.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-discovery-solutions.jpg/_jcr_content/renditions/original.image_file.360.203.file/drug-discovery-solutions.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-discovery-solutions.jpg/_jcr_content/renditions/original.image_file.768.432.file/drug-discovery-solutions.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-discovery-solutions.jpg/_jcr_content/renditions/original.image_file.1024.576.file/drug-discovery-solutions.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-discovery-solutions.jpg/_jcr_content/renditions/original.image_file.1280.720.file/drug-discovery-solutions.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-discovery-solutions.jpg/_jcr_content/renditions/original.image_file.1440.810.file/drug-discovery-solutions.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/drug-discovery-solutions.jpg/_jcr_content/renditions/original./drug-discovery-solutions.jpg"})
行业解决方案
药物发现 识别能够对抗疾病的靶点和先导化合物分子
![靶点识别:寻找疾病的弱点 靶点识别:寻找疾病的弱点]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-life-science-portfolio.jpg/_jcr_content/renditions/original.image_file.100.56.117,57,1874,1046.file/zeiss-life-science-portfolio.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-life-science-portfolio.jpg/_jcr_content/renditions/original.image_file.360.203.117,57,1874,1046.file/zeiss-life-science-portfolio.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-life-science-portfolio.jpg/_jcr_content/renditions/original.image_file.768.432.117,57,1874,1046.file/zeiss-life-science-portfolio.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-life-science-portfolio.jpg/_jcr_content/renditions/original.image_file.1024.576.117,57,1874,1046.file/zeiss-life-science-portfolio.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-life-science-portfolio.jpg/_jcr_content/renditions/original.image_file.1280.720.117,57,1874,1046.file/zeiss-life-science-portfolio.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-life-science-portfolio.jpg/_jcr_content/renditions/original.image_file.1440.810.117,57,1874,1046.file/zeiss-life-science-portfolio.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zeiss-life-science-portfolio.jpg/_jcr_content/renditions/original.image_file.1757.988.117,57,1874,1046.file/zeiss-life-science-portfolio.jpg"})
靶点识别:寻找疾病的弱点
在制定疾病预防、治疗或恢复的策略时,需要对病理生理学有全面深刻的了解。其中包括细胞通路和疾病特异性组织生物标志物,它们可以提供有关可能产生积极结果的潜在药物靶点的信息。
![先导化合物识别:谁能命中靶点? 先导化合物识别:谁能命中靶点?]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/lead-identification-solutions.jpg/_jcr_content/renditions/original.image_file.100.75.129,246,1919,1590.file/lead-identification-solutions.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/lead-identification-solutions.jpg/_jcr_content/renditions/original.image_file.360.270.129,246,1919,1590.file/lead-identification-solutions.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/lead-identification-solutions.jpg/_jcr_content/renditions/original.image_file.768.576.129,246,1919,1590.file/lead-identification-solutions.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/lead-identification-solutions.jpg/_jcr_content/renditions/original.image_file.1024.768.129,246,1919,1590.file/lead-identification-solutions.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/lead-identification-solutions.jpg/_jcr_content/renditions/original.image_file.1280.960.129,246,1919,1590.file/lead-identification-solutions.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/lead-identification-solutions.jpg/_jcr_content/renditions/original.image_file.1440.1080.129,246,1919,1590.file/lead-identification-solutions.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/lead-identification-solutions.jpg/_jcr_content/renditions/original.image_file.1790.1343.129,246,1919,1590.file/lead-identification-solutions.jpg"})
样品由德国波恩神经退行性疾病中心(DZNE)核心研究机构的P. Denner提供。
先导化合物识别:谁能命中靶点?
在专注于正确的靶点时,您还必须谨慎识别出具有开发成突破性药物潜力的先导化合物分子,以尽可能减少在药物研发后期常见的因高损耗率而导致的成本。
为了研发出高特异度和疗效好的药物,药物发现工作正日益从简单的检测转为能够捕获大量参数的精细、高内涵的筛选方法。将样品类型从传统二维细胞培养扩展到生理学上更相关的三维细胞模型和类器官时,以及从端点检测转向活细胞检测时,复杂性会随之增加。尽管这些变化有望提高识别出更好的候选药的可能性,但同时也对成像技术提出了新的挑战。