![药物发现中的先导化合物识别——用于高内涵筛选的集成式端到端解决方案 药物发现中的先导化合物识别——用于高内涵筛选的集成式端到端解决方案]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/lead-identification-solutions.jpg/_jcr_content/renditions/original.image_file.100.100.file/lead-identification-solutions.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/lead-identification-solutions.jpg/_jcr_content/renditions/original.image_file.360.360.file/lead-identification-solutions.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/lead-identification-solutions.jpg/_jcr_content/renditions/original.image_file.768.768.file/lead-identification-solutions.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/lead-identification-solutions.jpg/_jcr_content/renditions/original.image_file.1024.1024.file/lead-identification-solutions.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/lead-identification-solutions.jpg/_jcr_content/renditions/original.image_file.1280.1280.file/lead-identification-solutions.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/lead-identification-solutions.jpg/_jcr_content/renditions/original.image_file.1440.1440.file/lead-identification-solutions.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/lead-identification-solutions.jpg/_jcr_content/renditions/original./lead-identification-solutions.jpg"})
药物发现中的先导化合物识别
用于高内涵筛选的集成式端到端解决方案
现有科学技术的能力和我们对细胞生物学的了解达到了前所未有的水平,然而矛盾的是,药物研发的淘汰率尚未有明显改善。随着实验方法的日益复杂以及可用数据采集和分析技术的日益进步,药物研发的成功不仅仅在于新技术的功能,而是在很大程度上取决于您利用技术优势的能力。蔡司高内涵成像工具系列是改善药物发现管道输出的解决方案的一部分。
![集成式端到端筛选解决方案 集成式端到端筛选解决方案]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/illustration-pharma-drug-development.png/_jcr_content/renditions/original.image_file.100.56.0,0,1919,1082.file/illustration-pharma-drug-development.png","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/illustration-pharma-drug-development.png/_jcr_content/renditions/original.image_file.360.203.0,0,1919,1082.file/illustration-pharma-drug-development.png","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/illustration-pharma-drug-development.png/_jcr_content/renditions/original.image_file.768.432.0,0,1919,1082.file/illustration-pharma-drug-development.png","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/illustration-pharma-drug-development.png/_jcr_content/renditions/original.image_file.1024.576.0,0,1919,1082.file/illustration-pharma-drug-development.png","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/illustration-pharma-drug-development.png/_jcr_content/renditions/original.image_file.1280.720.0,0,1919,1082.file/illustration-pharma-drug-development.png","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/illustration-pharma-drug-development.png/_jcr_content/renditions/original.image_file.1440.810.0,0,1919,1082.file/illustration-pharma-drug-development.png","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/illustration-pharma-drug-development.png/_jcr_content/renditions/original.image_file.1919.1079.0,0,1919,1082.file/illustration-pharma-drug-development.png"})
集成式端到端筛选解决方案
![集成式端到端筛选解决方案 集成式端到端筛选解决方案]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/illustration-pharma-drug-development.png/_jcr_content/renditions/original.image_file.100.56.file/illustration-pharma-drug-development.png","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/illustration-pharma-drug-development.png/_jcr_content/renditions/original.image_file.360.203.file/illustration-pharma-drug-development.png","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/illustration-pharma-drug-development.png/_jcr_content/renditions/original.image_file.768.432.file/illustration-pharma-drug-development.png","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/illustration-pharma-drug-development.png/_jcr_content/renditions/original.image_file.1024.576.file/illustration-pharma-drug-development.png","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/illustration-pharma-drug-development.png/_jcr_content/renditions/original.image_file.1280.720.file/illustration-pharma-drug-development.png","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/illustration-pharma-drug-development.png/_jcr_content/renditions/original.image_file.1440.810.file/illustration-pharma-drug-development.png","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/illustration-pharma-drug-development.png/_jcr_content/renditions/original./illustration-pharma-drug-development.png"})
集成的端到端筛选解决方案。
1) 通过ZEN API灵活集成机器人和外部硬件。
2) 借助Celldiscoverer 7成像系统和ZEN图像采集软件实现自动化的高内涵成像工作流。
3) arivis Pro:强大的图像分析管道,以提炼出可操作的宝贵见解。
4) arivis visionHub:提供可扩展、基于服务器的高性能分析和远程访问,协助高效开展大型研究。
集成的端到端筛选解决方案。
1) 通过ZEN API灵活集成机器人和外部硬件。
2) 借助Celldiscoverer 7成像系统和ZEN图像采集软件实现自动化的高内涵成像工作流。
3) arivis Pro:强大的图像分析管道,以提炼出可操作的宝贵见解。
4) arivis visionHub:提供可扩展、基于服务器的高性能分析和远程访问,协助高效开展大型研究。
技术构建模块的无缝集成
为您的高级筛选工作提供高效解决方案
蔡司ZEN软件是您实验的核心,它可以访问所有成像参数——无论该参数来自简单图像还是高维的多模态图像采集,并可将其整合到全自动的工作流程中。此外,ZEN还是中央通讯枢纽,它通过可用的API与您的机器人孔板装载机和其他第三方硬件组件进行交互。
ZEN软件可以助您轻松过渡到arivis Pro软件并设置强大的二维、三维及其他图像分析管道,为您提供可操作的数据。其高效的处理框架使您能够在标准的笔记本电脑或台式电脑上设置分析管道,可轻松处理超大数据集。
图像分析管道一旦经过验证,您便可以通过使用基于服务器的高性能arivis VisionHub分析软件进行扩展,该软件在本地或云端皆可使用。最后,ZEN软件还支持您进行远程访问,轻松实现共享数据和合作,助您提高工作效率,在跨多个站点进行大型研究时尽享优势。
![神经球样品由德国马格德堡LSM Bioanalytik GmbH的H. Braun提供。 神经球样品由德国马格德堡LSM Bioanalytik GmbH的H. Braun提供。]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.100.56.0,0,1917,1079.file/early-basic-research.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.360.203.0,0,1917,1079.file/early-basic-research.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.768.432.0,0,1917,1079.file/early-basic-research.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.1024.576.0,0,1917,1079.file/early-basic-research.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.1280.720.0,0,1917,1079.file/early-basic-research.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.1440.810.0,0,1917,1079.file/early-basic-research.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.1917.1078.0,0,1917,1079.file/early-basic-research.jpg"})
神经球样品由德国马格德堡LSM Bioanalytik GmbH的H. Braun提供。
![神经球样品由德国马格德堡LSM Bioanalytik GmbH的H. Braun提供。 神经球样品由德国马格德堡LSM Bioanalytik GmbH的H. Braun提供。]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.100.56.file/early-basic-research.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.360.203.file/early-basic-research.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.768.432.file/early-basic-research.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.1024.576.file/early-basic-research.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.1280.720.file/early-basic-research.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original.image_file.1440.810.file/early-basic-research.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/early-basic-research.jpg/_jcr_content/renditions/original./early-basic-research.jpg"})
神经球样品由德国马格德堡LSM Bioanalytik GmbH的H. Braun提供。
神经球样品由德国马格德堡LSM Bioanalytik GmbH的H. Braun提供。
具有出色质量的高内涵筛选
将您的药物发现提升至新水平
凭借出色的数据质量和不断完善的检测数据,您能够识别非常有潜力推向临床的先导化合物候选药。蔡司高内涵成像解决方案可以提供以下支持,促进您的药物发现取得成功:
- 更多的参数,如更多标签和维度,包括活细胞实验的时域
- 更高的信息密度,其得益于更高的分辨率和更快的动态
- 更高的生理相关性——从较为简单的二维细胞培养转为复杂的三维模型,如细胞球、类器官和器官芯片或微生理系统。
![Celldiscoverer 7 Celldiscoverer 7]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/products/imaging/celldiscoverer/celldiscoverer_large_system_1x1.jpg/_jcr_content/renditions/original.image_file.100.100.file/celldiscoverer_large_system_1x1.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/products/imaging/celldiscoverer/celldiscoverer_large_system_1x1.jpg/_jcr_content/renditions/original.image_file.360.360.file/celldiscoverer_large_system_1x1.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/products/imaging/celldiscoverer/celldiscoverer_large_system_1x1.jpg/_jcr_content/renditions/original.image_file.768.768.file/celldiscoverer_large_system_1x1.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/products/imaging/celldiscoverer/celldiscoverer_large_system_1x1.jpg/_jcr_content/renditions/original.image_file.1024.1024.file/celldiscoverer_large_system_1x1.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/products/imaging/celldiscoverer/celldiscoverer_large_system_1x1.jpg/_jcr_content/renditions/original.image_file.1280.1280.file/celldiscoverer_large_system_1x1.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/products/imaging/celldiscoverer/celldiscoverer_large_system_1x1.jpg/_jcr_content/renditions/original.image_file.1440.1440.file/celldiscoverer_large_system_1x1.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/products/imaging/celldiscoverer/celldiscoverer_large_system_1x1.jpg/_jcr_content/renditions/original./celldiscoverer_large_system_1x1.jpg"})
蔡司Celldiscoverer 7:全自动高内涵成像
Celldiscoverer 7能够筛选固定和活体样品,其范围从培养皿或多孔板中的二维组织培养物到三维培养物和类器官。它可以与蔡司Airyscan技术结合使用,提供超越传统共聚焦分辨率的三维分辨率和出色的灵敏度,即使对微弱的信号也能实现可视化,而不会产生光毒性效应。
![使用蔡司ZEN自动检测生物样品中的荧光标记细胞核 使用蔡司ZEN自动检测生物样品中的荧光标记细胞核]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zen-bio-apps.png/_jcr_content/renditions/original.image_file.100.75.123,0,996,655.file/zen-bio-apps.png","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zen-bio-apps.png/_jcr_content/renditions/original.image_file.360.270.123,0,996,655.file/zen-bio-apps.png","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zen-bio-apps.png/_jcr_content/renditions/original.image_file.768.576.123,0,996,655.file/zen-bio-apps.png","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zen-bio-apps.png/_jcr_content/renditions/original.image_file.873.655.123,0,996,655.file/zen-bio-apps.png","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zen-bio-apps.png/_jcr_content/renditions/original.image_file.873.655.123,0,996,655.file/zen-bio-apps.png","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zen-bio-apps.png/_jcr_content/renditions/original.image_file.873.655.123,0,996,655.file/zen-bio-apps.png","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zen-bio-apps.png/_jcr_content/renditions/original.image_file.873.655.123,0,996,655.file/zen-bio-apps.png"})
使用蔡司ZEN自动检测生物样品中的荧光标记细胞核
![使用蔡司ZEN自动检测生物样品中的荧光标记细胞核 使用蔡司ZEN自动检测生物样品中的荧光标记细胞核]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zen-bio-apps.png/_jcr_content/renditions/original.image_file.100.66.file/zen-bio-apps.png","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zen-bio-apps.png/_jcr_content/renditions/original.image_file.360.237.file/zen-bio-apps.png","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zen-bio-apps.png/_jcr_content/renditions/original.image_file.768.505.file/zen-bio-apps.png","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zen-bio-apps.png/_jcr_content/renditions/original./zen-bio-apps.png","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zen-bio-apps.png/_jcr_content/renditions/original./zen-bio-apps.png","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zen-bio-apps.png/_jcr_content/renditions/original./zen-bio-apps.png","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/zen-bio-apps.png/_jcr_content/renditions/original./zen-bio-apps.png"})
使用蔡司ZEN自动检测生物样品中的荧光标记细胞核
使用蔡司ZEN自动检测生物样品中的荧光标记细胞核
稳健可靠的数据
在新药研发中取得成功
蔡司高内涵成像解决方案可凭借多方优势生成准确稳定的数据。
- 首先,蔡司Celldiscoverer 7凭借出色的成像技术以低光毒性的成像方式生成高质量数据,保护您的样品免受光致扰动。
- 其次,蔡司提供高质量的培训和支持资源,即使是新手用户也能充分利用该技术,从一开始就为成功奠定基础。
- 再次,ZEN图像采集参数和arivis Pro图像分析管道均可集成至全自动工作流中,使数据输出在用户之间和整个研究时间范围内完全一致且可重现。
- 最后,可扩展的arivis VisionHub分析与数据管理平台包括透明用户管理和审计追踪功能,确保您的结果完全可追溯,在处理大型和复杂的数据集时也同样如此。
![Celldiscoverer 7——细节图 Celldiscoverer 7——细节图]({"xsmall":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/celldiscoverer7_details.jpg/_jcr_content/renditions/original.image_file.100.67.0,0,1917,1278.file/celldiscoverer7_details.jpg","small":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/celldiscoverer7_details.jpg/_jcr_content/renditions/original.image_file.360.240.0,0,1917,1278.file/celldiscoverer7_details.jpg","medium":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/celldiscoverer7_details.jpg/_jcr_content/renditions/original.image_file.768.512.0,0,1917,1278.file/celldiscoverer7_details.jpg","large":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/celldiscoverer7_details.jpg/_jcr_content/renditions/original.image_file.1024.683.0,0,1917,1278.file/celldiscoverer7_details.jpg","xlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/celldiscoverer7_details.jpg/_jcr_content/renditions/original.image_file.1280.853.0,0,1917,1278.file/celldiscoverer7_details.jpg","xxlarge":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/celldiscoverer7_details.jpg/_jcr_content/renditions/original.image_file.1440.960.0,0,1917,1278.file/celldiscoverer7_details.jpg","max":"https://www.zeiss.com/content/dam/rms/reference-master/applications/life-sciences/pharmaceutical-biotech-industry/celldiscoverer7_details.jpg/_jcr_content/renditions/original.image_file.1917.1278.0,0,1917,1278.file/celldiscoverer7_details.jpg"})
易用性和灵活性
自动化工作流和定制化
简单的自动化工作流可高效可靠地运作,用户操作失误的风险低,因此非常适合用于大规模的药物发现。然而,由于突破性疗法的成功发现建立在探索未知的基础上,您仍需要能够灵活对成像参数和工作流程进行微调,以采集到所需要的精准数据。
蔡司高内涵成像解决方案采用易于操作的工作流程,可针对所研究问题的复杂性进行调适。我们的工作流自动化可以在不牺牲任何构建模块功能的情况下,涵盖第三方硬件、图像采集、处理和分析。
此外,如果您需要一个无法从现有组件轻松编制的特定解决方案,蔡司Solutions Lab团队可时刻为您扩展可能性并定制个性化解决方案,让您可以对数据采集过程进行微调、实现自动化数据分析并简化整个工作流。
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* 本页所示图像仅为研究内容。蔡司明确排除基于Axioscan 7玻片扫描仪生成的信息对可能受影响的患者进行诊断或推荐治疗的可能性。