Healthy Sleep, Healthy Eyes
New insights into myopia prevention

Clinical Research | ZEISS Vision Care
A global health concern that affects approximately 2 billion people worldwide1: myopia prevalence continues to rise, particularly among children and adolescents in East and Southeast Asia.2 Identifying modifiable risk factors that help control the onset and progression of the condition has become an urgent priority. In this regard, research has provided interesting and new insights into the relationship between sleep patterns and myopia.3-6 This is emerging as an important area for myopia research.7
Sleep plays a crucial role in children’s overall health, serving as a foundation for optimal daily functioning, as well as physical and mental well-being. Insufficient sleep has been linked to various health issues, including childhood obesity and psychosocial challenges.8 Its role in myopia, however, is less well understood.
Emerging evidence: sleep and myopia
Recent systematic reviews, collectively analysing data from over 250,000 participants, have explored the relationship between sleep patterns and myopia development.3-5 While there is much work to be done to fully understand the relation between sleep and myopia, the findings suggest that sleep may be a modifiable risk factor for myopia.
Sleep duration: a key consideration
Longer or sufficient nighttime sleep may lower the risk for myopia. A 37% reduction in risk was found with a meta-analysis.5 However, this finding remains to be validated with others not finding similar correlation. But importantly, short sleep duration has been more consistently linked to increased myopia risk, with the analysis reporting a 66% higher risk among children with insufficient sleep.5
Why might duration of sleep be an important factor? This association may be explained by the disruption of normal circadian rhythms, which play a critical role in regulating eye growth.9 Short sleep duration, particularly at night, may interfere with the natural growth and remodelling cycles of the eye, contributing to excessive elongation and myopia development.
Sleep quality: beyond quantity
In addition to duration, sleep quality has emerged as an important factor. Across studies, poor sleep quality has consistently been associated with higher myopia risk.3-5 The mechanisms linking sleep quality and myopia may involve disruptions to circadian rhythms and alterations in dopamine signalling, both of which are known to influence eye development.9,10
Sleep timing and pattern
While the relationship between sleep timing and pattern and myopia is more complex and therefore less consistent than those of sleep duration and quality, emerging evidence suggests important connections. Later bedtimes have been associated with increased risk of myopia onset and progression in school-aged children.11 The mechanism may involve disruption of circadian rhythms that regulate eye growth patterns. Recent research has revealed that myopic individuals demonstrate delayed circadian timing compared to non-myopes,12 suggesting fundamental differences in their biological rhythms. This timing effect extends to physical eye changes: study found associations between late bedtimes and reduced diurnal variations in axial length, with delays in bedtime correlating with axial length increases.13
Sleep patterns and consistency also play crucial roles. Greater variability in sleep-wake schedules, particularly between weekdays and weekends, has been associated with myopia in children.14 This "social jetlag" effect may again disrupt the natural rhythms of eye growth and recovery, as normal eyes typically demonstrate consistent patterns of growth during the day and shrinkage at night. The evidence suggests that both timing and regularity of sleep may be important factors in eye development and myopia risk, highlighting the need for consistent sleep schedules aligned with natural circadian rhythms.
Biological mechanisms linking sleep and myopia
Several biological mechanisms may explain the connection between sleep and myopia:
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The human eye follows circadian patterns, elongating during the day and shrinking at night. Disrupted sleep may interfere with this natural rhythm, contributing to abnormal eye growth patterns and risk of myopia development and progression.9
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Sleep deprivation may alter dopamine receptor activity in the brain,15 which is thought to influence eye growth and the development of refractive errors.16
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Adequate sleep may provide essential recovery time for eye tissues and help regulate growth factors involved in ocular development.17
Implications for myopia
The relationship between sleep and myopia offers an opportunity for addressing the global myopia epidemic. Sufficient sleep duration is consistently associated with reduced myopia risk, while poor sleep quality, late timing, and irregular sleep patterns appear to increase risk, particularly in children and adolescents. These findings underscore the potential of incorporating sleep health into comprehensive myopia prevention strategies.
Promoting sleep health represents a low-risk, cost-effective approach that complements existing prevention methods. This is especially relevant in East and Southeast Asian countries, where myopia prevalence is highest, and academic pressures often interfere with healthy sleep patterns. Although further research is required to fully understand the interactions between sleep and eye development, current evidence supports the integration of sleep health education into myopia prevention programs. Targeting the critical developmental years, this practical, evidence-based strategy could significantly contribute to curbing the myopia epidemic while simultaneously improving overall health and well-being.
Promoting sleep health represents a low-risk, cost-effective approach that complements existing prevention methods.

Promoting healthy sleep habits
To reduce myopia risk and slow progression, public health initiatives and clinical recommendations should emphasize the following:
- Adequate Sleep Duration: Encouraging adherence to age-specific guidelines for sleep. The National Sleep Foundation's widely-adopted guidelines recommended:18
- Preschoolers (3-5 years): 10-13 hours
- School-age children (6-13 years): 9-11 hours
- Teenagers (14-17 years): 8-10 hours
- Young adults (18-25 years): 7-9 hours
- Consistent Sleep Schedule: Maintaining regular sleep-wake patterns, even on weekends.
- Good Sleep Hygiene: Limiting screen time before bedtime, as electronic devices delay melatonin release and disrupt sleep timing.19
Integrating sleep into eye health programs
Eye care professionals should include sleep-related factors in patient history-taking and educational efforts. Spending more time outdoors during the day—already a key recommendation for myopia prevention—can also improve sleep quality and circadian rhythm regulation,20 further reducing myopia risk.
By integrating sleep health education into myopia prevention strategies, we can address the growing burden of myopia more comprehensively. This holistic approach not only targets myopia prevention but also supports broader public health goals, promoting better sleep habits for improved overall well-being.
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1
Holden BA, Fricke TR, Wilson DA, et al. Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050. Ophthalmology. May 2016;123(5):1036-42. doi:10.1016/j.ophtha.2016.01.006
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2
Sankaridurg P, Tahhan N, Kandel H, et al. IMI Impact of Myopia. Invest Ophthalmol Vis Sci. Apr 28 2021;62(5):2. doi:10.1167/iovs.62.5.2
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3
Liu XN, Naduvilath TJ, Sankaridurg PR. Myopia and sleep in children—a systematic review. Sleep. 2023;doi:10.1093/sleep/zsad162
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4
Jin E, Lee CE, Li H, Tham Y-C, Chen DZ. Association between sleep and myopia in children and adolescents: a systematic review and meta-analysis. Graefe's Archive for Clinical and Experimental Ophthalmology. 2024/07/01 2024;262(7):2027-2038. doi:10.1007/s00417-023-06338-0
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5
Wang XX, Liu X, Lin Q, Dong P, Wei YB, Liu JJ. Association between sleep duration, sleep quality, bedtime and myopia: A systematic review and meta-analysis. Clin Exp Ophthalmol. Sep-Oct 2023;51(7):673-684. doi:10.1111/ceo.14277
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6
Biswas S, El Kareh A, Qureshi M, et al. The influence of the environment and lifestyle on myopia. J Physiol Anthropol. Jan 31 2024;43(1):7. doi:10.1186/s40101-024-00354-7
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7
Morgan IG, Wu PC, Ostrin LA, et al. IMI Risk Factors for Myopia. Invest Ophthalmol Vis Sci. Apr 28 2021;62(5):3. doi:10.1167/iovs.62.5.3
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8
Matricciani L, Paquet C, Galland B, Short M, Olds T. Children's sleep and health: A meta-review. Sleep Med Rev. Aug 2019;46:136-150. doi:10.1016/j.smrv.2019.04.011
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9
Chakraborty R, Ostrin LA, Nickla DL, Iuvone PM, Pardue MT, Stone RA. Circadian rhythms, refractive development, and myopia. Ophthalmic and Physiological Optics. 2018;38(3):217-245. doi:doi:10.1111/opo.12453
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10
Feldkaemper M, Schaeffel F. An updated view on the role of dopamine in myopia. Exp Eye Res. Sep 2013;114:106-19. doi:10.1016/j.exer.2013.02.007
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11
Liu XN, Naduvilath TJ, Wang J, et al. Sleeping late is a risk factor for myopia development amongst school-aged children in China. Scientific reports. 14 Oct 2020;10(1):17194. doi:https://dx.doi.org/10.1038/s41598-020-74348-7
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12
Chakraborty R, Micic G, Thorley L, et al. Myopia, or near-sightedness, is associated with delayed melatonin circadian timing and lower melatonin output in young adult humans. Sleep. Mar 12 2021;44(3)doi:10.1093/sleep/zsaa208
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13
Liu XN, Yap SEL, Chen XE, Philip K, Naduvilath TJ, Sankaridurg PR. Late Bedtime and Altered Diurnal Axial Length Rhythms of the Eye. Curr Eye Res. Sep 4 2024:1-9. doi:10.1080/02713683.2024.2396383
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14
Ostrin LA, Read SA, Vincent SJ, Collins MJ. Sleep in myopic and non-myopic children. Translational Vision Science and Technology. 2020;9(9):1-13. doi:http://dx.doi.org/10.1167/tvst.9.9.22
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15
Volkow ND, Tomasi D, Wang GJ, et al. Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain. J Neurosci. May 9 2012;32(19):6711-7. doi:10.1523/jneurosci.0045-12.2012
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16
Zhou X, Pardue MT, Iuvone PM, Qu J. Dopamine signaling and myopia development: What are the key challenges. Progress in Retinal and Eye Research. 2017/11/01/ 2017;61:60-71. doi:https://doi.org/10.1016/j.preteyeres.2017.06.003
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17
Stone RA, Pardue MT, Iuvone PM, Khurana TS. Pharmacology of myopia and potential role for intrinsic retinal circadian rhythms. Experimental Eye Research. 2013/09/01/ 2013;114:35-47. doi:https://doi.org/10.1016/j.exer.2013.01.001
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18
Hirshkowitz M, Whiton K, Albert SM, et al. National Sleep Foundation's sleep time duration recommendations: methodology and results summary. Sleep Health. Mar 2015;1(1):40-43. doi:10.1016/j.sleh.2014.12.010
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19
Hysing M, Pallesen S, Stormark KM, Jakobsen R, Lundervold AJ, Sivertsen B. Sleep and use of electronic devices in adolescence: results from a large population-based study. BMJ Open. Feb 2 2015;5(1):e006748. doi:10.1136/bmjopen-2014-006748
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20
Burns AC, Saxena R, Vetter C, Phillips AJK, Lane JM, Cain SW. Time spent in outdoor light is associated with mood, sleep, and circadian rhythm-related outcomes: A cross-sectional and longitudinal study in over 400,000 UK Biobank participants. J Affect Disord. Dec 1 2021;295:347-352. doi:10.1016/j.jad.2021.08.056