Pharma & Healthcare

Drug dissolution testing is used by the pharmaceutical industry to guide formulation and control product quality. A solution of the dosage form (tablet, capsule etc.) is made and the rate of in vitro drug release is monitored over time giving information about batch-to batch consistency of the manufacturing process and (in limited cases) in vivo drug release profiles. ZEISS spectrophotometers like the MMS UV-VIS series are an excellent choice to monitor dissolution baths. The design combines maximum throughput with good resolution as well as long-term stable wavelength calibration and minimum stray light in the sensor for precise analytical results.

US FDA process analytical technology (PAT) is guidance to optimize and control pharmaceutical & food manufacturing through standardized quality control and the documentation of critical variables during production (at-line, on-line and in-line). NIR spectroscopy provides an invaluable tool in achieving compliance with the PAT framework, especially for in-line processes and incoming goods inspection. NIR spectrometers like the PGS series deliver real-time data as probes can easily be mounted within process streams and NIR instruments measure through packaging such as glass vials and the blister packs of plastic bags.  MCS CCD  spectrometers can be used to control the cleaning process between production batches, whereas  MMS UV and MMS UV-VIS spectrophotometers cover PAT guidance for waste water treatment by the non-destructive monitoring of waste water constituents from ongoing production (see industrial waste water).